mess with sb/sth phr v [T] don't mess withspoken 【口】 a) used to warn someone not to annoy another person 别惹怒，别去招惹: Don't mess with me, buddy! 别惹我，老兄！ b) used to warn someone not to get involved with something dangerous 别和〔危险的东西〕扯上关系; 不要沾染: Don't mess with drugs. 不要沾染毒品。